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Amantadine - Symmetrel®

Used for

 

Striking anti depressive effects in some patients have been attributed to its antiviral activity against human Borna disease virus (BDV) infection which is frequently seen in patients with depressive episodes. In an 8 to 12 week open study of oral amantadine in 30 depressed patients with various states of BDV infection there was found a significant anti depressive response in 19 of 30 patients. Peripheral BDV antigen indicating acute infection was cleared in both responders and non-responders, but only in responders was  peripheral infection significantly reduced.

 

Side effects may occur                                                                                                                    

 

 

 

1. Krupp LB, et al. Fatigue therapy in multiple sclerosis: results of a double-blind, randomised, parallel trial of amantadine, pemoline, and placebo. Neurology 1995;45(11):1956-1961.

 

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