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If you have experienced any adverse side effects from a medication or therapy -
Mitoxantrone - Novantrone®
Belongs to the general group of medicines called antineoplastics.
Adverse side effects may occur
- Exceeding a certain cumulative effect may be toxic for the heart.
- Secondary leukaemia
- Secondary acute myelogenous leukaemia (AML) has been reported in MS and cancer patients treated with Novantrone.
- Post-
marketing cases of secondary AML have also been reported. - Increased chance of infections.
Prior to its approval for use in MS, it was used only to treat certain forms of cancer. It acts in MS by suppressing the activity of T cells, B cells, and macrophages that are thought to lead the attack on the myelin sheath.
Is indicated for reducing neurologic disability and - or the frequency of clinical
relapses in patients with secondary progressive, progressive relapsing and worsening
relapsing-remitting MS. It is not indicated for primary progressive MS, or recommended
for MS patients with a certain blood cell count, liver function test, or cardiac
abnormalities; or for women who plan to become, or are pregnant.
Normally, blood cells are made in the bone marrow in an orderly and controlled way. In acute myeloid leukaemia (AML), this process gets out of control and many abnormal leukaemia cells are made. These cells are immature and aren’t able to develop into normal functioning blood cells.
The immature cells fill up the bone marrow, taking up space that is needed to make normal blood cells. Some leukaemia cells 'spill over' into the blood and circulate around the body in the bloodstream.
These leukaemia cells don’t mature, and so don’t work properly. This leads to an increased risk of infection as well as symptoms such as anaemia and bruising caused by fewer healthy red blood cells and platelets being made.
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