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Stem Cell Therapy - MS                                                         

We are following the development of stem cell research with great interest although the jury still seems out on what this therapy may have to offer sufferers of neurological conditions right now. There have been articles about fantastic improvements in some cases of MS although our initial excitement has more recently been tempered somewhat by a certain lack of follow-up in certain quarters and by the appearance of one or two less professional set-ups with a decidedly financial bias to their work!

 

We still believe that there is a great future for this method of treatment but for the moment we think that more evidence, pursued along more rigorous scientific approaches, is necessary before we can wholehearted endorse this approach. Indeed several Proventus members have followed this route but their results have been nowhere near as dramatic as those published in the media  sometimes they have been completely unimproved while others even found themselves definitely worse.

 

What follows is hopefully a more balanced perspective on the state of current stem cell thinking.

 

Proventus contacted Prof. Raisman to ask for his views on stem cell transplant therapy in relation to neurological conditions and disease processes (as opposed to his own work on the beneficial effects in nerve injury).

 

Prof Raisman moved into Queens Square, London December 2005 under the auspices of the Institute of Neurology and University College, London.

 

This is because he and his 6-strong team now have permission for the first preliminary study, which begins this autumn, as a result of his dogged refusal to give up the fight to succeed. He feels he is on to a major breakthrough and moreover he has the scientific community's increasing support

He felt that conditions such as MS were a particularly difficult area where this therapy was concerned primarily because of their diffuse and widespread natures and often as progressive diseases whose origins were not fully understood.

 

Even if there were to be an initial positive response the MS (as an example) progression may well resume after a short period owing to the fact that the fundamental condition had not been cured and may well be ongoing under the surface.

 

Prof Geoff Raisman FRS

A Leeds University-educated world-class neuroscientist, has just announced that he is confident of an imminent breakthrough in spinal cord injury treatment that may well become at least a partial cure for serious damage to this vital message highway.

 

Below is a precis of a six-page article from the Sunday Times magazine (April 06 9th edition-report by John Cornwell). It has taken 40 years of painstaking focused research to achieve the current position. Stem cells are the key to his research, but the cells are not from embryos, umbilical cords, or bone marrow.

 

Prof Raisman has worked on stem cells from the nose where olfactory nerve cells are replaced every 60 days. They form in the upper nose and, when they sprout nerve fibres, they are steered by the body processes to their connecting goals in the brain pathways.

 

They owe their guiding potential to their shape and have tiny porous canals, like Cadbury’s  Flake bars, through which the new nerve fibres grow and seek their corresponding partners across the gap or injury site.These fibrous arms “flap about” till they meet up with others on adjoining neurons

 

The basic strategy is to collect young stem cells from the patient, culture and cleanse them, and then inject them into the damaged site in the spinal cord, behind the scar tissue, in the hope they would guide the nerve fibres towards each other from either side of the scar.

 

There is now abundant laboratory clinical evidence that his strategy works well for there have been many remarkable recoveries by mice and rats described in detail.

 

Particular Concern                                                                                                                                                                                                                       

Over these past years many sufferers have been encouraged to travel to other countries from the UK  and elsewhere at great expense and effort. Private clinics have offered stem cell therapy treatment, more so as a treatment for some of the serious neurological, autoimmune diseases. The science has yet to be proven, some of the clinics were investigated and closed down.

 

Currently there is no scientific proof nor substantial anecdotal evidence that stem cell therapy is an effective treatment for many of the serious neurological, autoimmune diseases.    

 

 

Other web sites                                                                                                                                                                                                                             

stemcellresearch.org

stem-cells.com

 

 

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