Methicillin Resistant Staphylococcus Aureus - MRSA
Staphylococcus aureus - discovered in Aberdeen, Scotland in 1880 by the surgeon Sir
Alexander Ogston in pus from surgical abscesses. PubMed
Staphylococcus aureus is a very common type of bacterium which lives on the skin.
Often found in parts of the body such as the nose, the armpits and between the buttocks.
Generally this bacterium creates no problem to the person it is living on and may
protect the body in some way against more serious bacteria. However, Staphylococcus
can cause minor infections such as boils and abscesses or, in people with poor immunity,
can cause more serious life-threatening infections.
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for
difficult-to-treat infections in humans. It may also be referred to as multidrug-resistant
Staphylococcus aureus or oxacillin-resistant Staphylococcus aureus (ORSA).
MRSA is by definition a strain of Staphylococcus aureus that is resistant to a large
group of antibiotics known as the beta-lactams, which include the penicillins and
the cephalosporins.
The organism is often sub-categorized as:
- Community-Acquired MRSA (CA-MRSA).
- Health Care-Associated MRSA (HA-MRSA).
Some have defined CA-MRSA by criteria related to patients suffering from an MRSA
infection while others have defined CA-MRSA by genetic characteristics of the bacteria
themselves.
CA-MRSA strains were first reported in the late 1990's; these cases were defined
by a lack of exposure to the health care setting. In the next several years, it became
clear that CA-MRSA infections were caused by strains of MRSA that differed from the
older and better studied healthcare-associated strains.[1] The new CA-MRSA strains
have rapidly become the most common cause of cultured skin infections among individuals
seeking emergency medical care for these infections in urban areas of the United
States. These strains also commonly cause skin infections in athletes, jail and prison
detainees, and soldiers.
MRSA is a resistant variation of the common bacterium Staphylococcus aureus. It has
evolved an ability to survive treatment with beta-lactam antibiotics, including Methicillin,
Dicloxacillin, Nafcillin, and Oxacillin. MRSA is especially troublesome in hospital-associated
(nosocomial) infections.
- Ogston A (1984). "“On Abscesses”. Classics in Infectious Diseases". Rev Infect Dis
6 (1): 122–28
- Methicillin is a powerful type of penicillin which is generally only used for bacteria
which are resistant to less powerful antibiotics.
- Oxacillin is a penicillin antibiotic. It works by blocking the growth of the bacteria's
cell wall, resulting in the death of the bacteria.
- Nosocomial infections are infections which are a result of treatment in a hospital
or a healthcare service unit, but secondary to the patient's original condition.
Infections are considered nosocomial if they first appear 48 hours or more after
hospital admission or within 30 days after discharge.
Nosocomial - from the Greek word nosokomeion meaning hospital (nosos = disease, komeo
= to take care of).
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OSCN - Oxythiocyanate
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