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Acts to deplete immune cells called B cells 1 considered to play a role in the immune attack on the brain and spinal cord tissues. It is used in the treatment for :

B cell non-Hodgkin's lymphoma.

B-cell leukemias.

Some autoimmune diseases.

As an infusion it is administered every two weeks.

Safety and efficacy are yet to be demonstrated.

Used For:

• MS - For primary-progressive multiple sclerosis. A study shows that rituximab may be an effective treatment in a subgroup of people with secondary progressive multiple sclerosis
• Arthritis - Approved for use against a form of arthritis.
• Lymphoma - Approved for use against certain types of lymphoma.

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Hauser SL et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med. 2008 Feb 14;358(7):676-88.

Primary source: American Academy of Neurology - Source reference: Ionete C, et al "Rituximab in secondary progressive multiple sclerosis -- one year follow up" AAN 2010; Abstract P02.147.Source: Medpage Today © 2004-2010 MedPage Today, LLC(19/04/10)

Serious side effects may occur such as:

• Infusion reaction
• Infections
• Serious Side effects may occur such as:
• Fatal injection reactions.
• Progressive multifocal leukoencephalopathy (PML) - also known as progressive multifocal leukoencephalitis, a rare and usually fatal viral disease.

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Report Side Effects - Site Page

Rituximab - Rituxan