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Tovaxin                   

An autologous T-cell vaccine, which means it is prepared from a sample of the patient's own cells. Myelin-reactive T-cells are extracted from the blood and irradiated to produce a vaccine. When the vaccine is injected, the body sees these modified T-cells as being foreign and attacks them, priming the immune system to attack non-irradiated, myelin-reactive T-cells as well. The prepared vaccine is injected under the skin.

To produce the Tovaxin vaccine, Opexa uses its innovative T-cell platform to isolate MRTCs from an MS patient’s blood and then expand them ex vivo to create an appropriate therapeutic dose. The attenuated T-cells, which comprise the Tovaxin vaccine, are then reintroduced into the patient via subcutaneous injection to trigger the immune system to attack that patient’s specific MRTCs.

 

In a small preliminary study, the drug demonstrated promise, reducing relapses by 90%.

 

Tovaxin possesses a unique dual mechanism of action that combats the demyelination of the nerve fibers in the central nervous system, the underlying cause of MS. Clinical results have demonstrated that Tovaxin produces the following therapeutic effects:

Anti-idiotypic effect - The vaccine induces an immune response that depletes the circulating pathogenic MRTCs (myelin reactive T-cells) that attack the myelin sheath of nerve fibers and cause the symptoms of MS.

Anti-ergotypic effect - Tovaxin also works to rebalance a patient’s overall immune system by causing a shift from pathogenic inflammatory T-cells to anti-inflammatory T-cells.

 

                                                                                                                                                                                                                                             

  1. Autologous refers to cells, tissues or even proteins that are reimplanted in the same individual that they come from
  2. T cells belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity.  The abbreviation T in T cell, stands for thymus, since it is the principal organ in the T cell's development.

 

Other web sites                                                                                                                                                                                                                             

opexatherapeutics.com

 

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