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Disease Modifying Drugs & Therapies

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Rituximab - Rituxan®                                                                                                                                                                                                                    

Acts to deplete immune cells called B cells [1] considered to play a role in the immune attack on the brain and spinal cord tissues. It is used in the treatment for :

• B cell non-Hodgkin's lymphoma.
• B-cell leukemias.
• Some autoimmune disorders.

As an infusion it is administered every two weeks.

Safety and efficacy are yet to be proven.

Side effects may occur                                                                                                                                                                                                                 

• Infusion reaction
• Infections

Adverse effects may occur                                                                                                                                                                                                          

Fatal injection reactions - Progressive multifocal leukoencephalopathy (PML) - also known as progressive multifocal leukoencephalitis, is a rare and usually fatal viral disease that is characterized by progressive damage or inflammation of the white matter of the brain at multiple locations.

It occurs almost exclusively in people with severe immune deficiency.

Used For

MS - For primary-progressive multiple sclerosis.

Arthritis - Approved for use against a form of arthritis.

Lymphoma - Approved for use against certain types of lymphoma.

1. Hauser SL et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med. 2008 Feb 14;358(7):676-88.

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